Cancer BiologybioRxiv
Targeting keratin 17-mediated reprogramming of de novo pyrimidine biosynthesis to overcome chemoresistance in pancreatic cancer
C.-H. Pan, N. Chaika, R. Tseng…·L. F. Escobar-Hoyos
This study identifies K17-mediated pyrimidine biosynthesis as a mechanism of chemoresistance in PDAC and shows that targeting DHODH with Brequinar enhances the efficacy of chemotherapy.
DOI 10.1158/0008-5472.can-25-4534