Author

R. Tseng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1

Frequent Co-Authors

C. V. Leiton· 2 shared C.-H. Pan· 2 shared K. R. Shroyer· 2 shared L. F. Escobar-Hoyos· 2 shared L. Roa-Pena· 2 shared M. A. Siraj· 2 shared S. Chowdhury· 2 shared A. Dey· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

C. V. Leiton

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Activation of ERK by altered RNA splicing in cancer

Y. Zhang, M. A. Siraj, P. Chakraborty, R. Tseng, L.-T. Ku, S. Das, A. Dey, S. K. D. Dwivedi, G. Rao, M. Zhang, D. Yang, M. N. Hossen, W.-Q. Ding, K.-M. Fung, R. Bhattacharya, , P. Mukherjee

The paper shows that SMNDC1, an upregulated splicing factor in cancer, promotes tumor growth by enhancing ERK1 kinase activity through altered RNA splicing of exon 4.

bioRxiv · Aug 31, 2022 · PreprintCancer Biology

Disassembly of embryonic keratin filaments promotes pancreatic cancer

R. R. Kawalerski, M. Torrente Goncalves, C.-H. Pan, R. Tseng, L. Roa-Pena, C. V. Leiton, L. A. Torre-Healy, T. Boyle, S. Chowdhury, N. T. Snider, K. R. Shroyer, L. F. Escobar-Hoyos

This study shows that phosphorylation of K17 promotes pancreatic cancer metastasis and shorter survival by disassembling keratin filaments and enabling nuclear translocation.

bioRxiv · Aug 27, 2022 · PreprintCancer Biology

Targeting keratin 17-mediated reprogramming of de novo pyrimidine biosynthesis to overcome chemoresistance in pancreatic cancer

C.-H. Pan, N. Chaika, R. Tseng, M. A. Siraj, B. Chen, K. L. Donnelly, M. Horowitz, C. V. Leiton, S. Chowdhury, L. Roa-Pena, L. Oblein, N. Marchenko, P. K. Singh, K. R. Shroyer, L. F. Escobar-Hoyos

This study identifies K17-mediated pyrimidine biosynthesis as a mechanism of chemoresistance in PDAC and shows that targeting DHODH with Brequinar enhances the efficacy of chemotherapy.

bioRxiv · Aug 24, 2022Cancer Biology