J. Moon

Endomucin regulates the endothelial cytoskeleton independent of VEGF

This study shows that endomucin regulates endothelial cytoskeleton dynamics in angiogenesis independently of VEGF signaling.

Systematic Analysis of Immune Changes after B-cell Depletion in Autoimmune Multiple Sclerosis

This study uses single-cell RNA sequencing to analyze immune changes after B-cell depletion in MS patients, revealing cell type-specific effects on macrophages, monocytes, and T cells.

Treatment of a genetic liver disease in mice through transient prime editor expression

This paper demonstrates transient prime editor expression in mice to correct a genetic liver disease, reducing blood phenylalanine levels below the therapeutic threshold.

Early viral infection of cyanobacteria drives bacterial chemotaxis in the oceans

This study shows that virus-infected cyanobacteria release metabolites that attract heterotrophic bacteria, enhancing nutrient transfer in marine ecosystems.

A Novel Subtype of Myeloproliferative Neoplasms Driven by a MYC-Alarmin Axis

This study identifies a MYC-S100A9 axis driving triple negative myelofibrosis and shows it is a therapeutic target.

Validity and reliability of a new whole room indirect calorimeter to assess metabolic response to small-calorie loads

The paper validates a whole room indirect calorimeter and applies Bayesian hierarchical modeling to assess metabolic responses to small-calorie loads.

Beclin1-Deficient Adipocytes Promote Tumor Progression by YAP/TAZ-dependent Adipocyte Transformation

This study shows that Beclin1-deficient adipocytes promote tumor progression via YAP/TAZ signaling, and inhibiting this pathway reduces tumor growth in mice.

Hematopoietic stem and progenitor cells integrate Bacteroides-derived innate immune signals to promote gut tissue repair

This study shows that Bacteroides activates HSPCs in the BM during acute gut inflammation to promote tissue repair, but impairs HSC function in chronic inflammation and aging.

Probing Neuro-Endocrine Interactions Through Wireless Magnetothermal Stimulation of Peripheral Organs

This study uses magnetothermal stimulation to investigate how stress affects the HPA axis in rats, finding that aversive conditioning alters adrenal function.

Stepwise transmigration cascade of T and B cells through the perivascular channel in lymph node high endothelial venules

This study uses intravital imaging to show T and B cells migrate through HEVs via distinct post-luminal steps involving ECs and FRCs, with T and B cells sharing trans-FRC hot spots but not trans-EC ones.

Population dynamics analysis of Saccharomyces cerevisiae deletion library during fed-batch cultivation using Bar-seq

The paper uses Bar-seq to analyze population dynamics of a yeast deletion library during fed-batch cultivation, identifying genes associated with stress responses in industrial fermentation.

IRF8 Governs Tumor-Associated Macrophage Control of T Cell Exhaustion

This study identifies IRF8 as a key factor in tumor-associated macrophages (TAMs) that induce T cell exhaustion by presenting cancer antigens, and shows its association with poor patient survival in renal cell carcinoma.

Meteorin-like (Metrnl) adipomyokine improves glucose tolerance in type 2 diabetes via AMPK pathway

This study shows that metrnl improves glucose tolerance in type 2 diabetes by activating the AMPK pathway and enhancing GLUT4 transcription.