Author

Y. Weber

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Organism:multiple species· 2 Research Focus:benchmarking· 1 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

A. Pearson· 4 shared A. Zhou· 4 shared W. D. Leavitt· 3 shared A. Cobban· 2 shared J. H. Rhim· 2 shared A. Cremonesi· 1 shared A. Maloney· 1 shared A. Talas· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersMicrobiology

A. Pearson

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Treatment of a genetic liver disease in mice through transient prime editor expression

T. Rothgangl, E. I. Ioannidi, Y. Weber, A. Talas, D. Boeck, M. Matsushita, E. A. Villiger, L. Schmidheini, J. Moon, P. J. C. Lin, S. H. Y. Fan, K. F. Marquart, C. Schwerdel, N. Rimann, E. Faccin, , G. Schwank

This paper demonstrates transient prime editor expression in mice to correct a genetic liver disease, reducing blood phenylalanine levels below the therapeutic threshold.

bioRxiv · Jan 22, 2024 · PreprintBioengineering

Metabolic imprints in the hydrogen isotopes of Archaeoglobus fulgidus tetraether lipids

J. H. Rhim, S. Kopf, J. McFarlin, A. Maloney, H. Batther, C. M. Harris, A. Zhou, X. Feng, Y. Weber, S. Hoeft-McCann, A. Pearson, W. D. Leavitt

This study investigates how metabolism and growth conditions affect hydrogen isotope signatures in archaeal lipids, supporting their use as paleohydrological proxies.

bioRxiv · Nov 29, 2023Microbiology

Ultrahigh throughput evolution of tryptophan synthase in droplets via an aptamer-biosensor

R. Scheele, Y. Weber, F. Nintzel, M. Herger, T. S. Kaminski, F. Hollfelder

This paper develops a DNA aptamer biosensor to enable high-throughput screening of tryptophan synthase variants in droplets, identifying 5-fold improved enzymes.

bioRxiv · Oct 11, 2023 · PreprintBiochemistry

Mode of carbon and energy metabolism shifts lipid composition in the thermoacidophile Acidianus

J. H. Rhim, A. Zhou, M. J. Amenabar, F. J. Elling, Y. Weber, A. Pearson, E. Boyd, W. D. Leavitt

This study shows that changes in energy and carbon metabolism in Acidianus sp. DS80 significantly affect the ring index of its membrane lipids, indicating a link between cellular energy state and lipid composition.

bioRxiv · Aug 10, 2023 · PreprintMicrobiology

Water column stability as an important factor controlling nitrite-dependent anaerobic methane oxidation in stratified lake basins

G. Su, M. Lehmann, J. Tischer, Y. Weber, J.-C. Walser, H. Niemann, J. Z. Zopfi

The paper investigates nitrite-dependent anaerobic methane oxidation in two lake basins, finding that stable low redox conditions are necessary for Candidatus Methylomirabilis to thrive, while fluctuating conditions hinder its growth.

bioRxiv · Nov 9, 2021 · PreprintMicrobiology

Multiple environmental parameters impact core lipid cyclization in Sulfolobus acidocaldarius

A. Cobban, Y. Zhang, A. Zhou, Y. Weber, A. Pearson, W. D. Leavitt

This study investigates how environmental factors affect lipid cyclization in Sulfolobus acidocaldarius, finding that growth rate correlates with cyclization and suggesting energy availability as a universal driver.

bioRxiv · Apr 23, 2020Microbiology

Energy flux controls tetraether lipid cyclization in Sulfolobus acidocaldarius

A. Zhou, B. Chiu, Y. Weber, F. Elling, A. Cobban, A. Pearson, W. Leavitt

This paper shows that energy flux affects GDGT cyclization in archaea, linking membrane composition to energy availability across different growth conditions.

bioRxiv · Aug 22, 2019Microbiology