Author

L. Sefer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. I. Magee· 2 shared C. E. Coupland· 2 shared C. Siebold· 2 shared E. W. Tate· 2 shared S. A. Andrei· 2 shared B. Pogranyi· 1 shared C. D. Johnston· 1 shared E. F. X. Byrne· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiophysics

A. I. Magee

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Author profile →

2 papers

Recent·Most cited

Structure and Mechanism of Hedgehog Acyl Transferase

C. E. Coupland, S. A. Andrei, T. B. Ansell, L. Carrique, P. Kumar, L. Sefer, R. A. Schwab, E. F. X. Byrne, E. Pardon, J. Steyaert, A. I. Magee, M. S. P. Sansom, E. W. Tate, C. Siebold

The paper presents the cryo-EM structure of HHAT, revealing its mechanism for transferring palmitate to SHH and identifying a heme group essential for its function.

bioRxiv · Jul 8, 2021 · PreprintBiophysics

Photochemical probe identification of the small-molecule binding site in a mammalian membrane-bound O-acyltransferase

T. Lanyon-Hogg, M. Ritzefeld, L. Zhang, B. Pogranyi, M. Mondal, C. D. Johnston, C. E. Coupland, L. Sefer, S. A. Andrei, J. Newington, A. I. Magee, C. Siebold, E. W. Tate

This study develops a photochemical probe to identify the small-molecule binding site in HHAT, leading to the discovery of a potent inhibitor and insights into MBOAT inhibition mechanisms.

bioRxiv · Oct 16, 2020 · PreprintBiochemistry