Photochemical probe identification of the small-molecule binding site in a mammalian membrane-bound O-acyltransferase
T. Lanyon-Hogg, M. Ritzefeld, L. Zhang, B. Pogranyi, M. Mondal, C. D. Johnston, C. E. Coupland, L. Sefer, S. A. Andrei, J. Newington, A. I. Magee, C. Siebold, E. W. Tate
This study develops a photochemical probe to identify the small-molecule binding site in HHAT, leading to the discovery of a potent inhibitor and insights into MBOAT inhibition mechanisms.
bioRxiv · Oct 16, 2020 · PreprintBiochemistry