Functional loss of a non-canonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation
L. M. Kutscher, K. Okonechnikov, N. V. Batora, J. Clark, P. B. G. Silva, M. Vouri, S. van Rijn, L. Sieber, B. Statz, M. D. Gearhart, N. Mack, B. A. Orr, A. Korshunov, A. L. Mercier, O. Ayrault, , D. Kawauchi
This study shows that loss of BCOR in SHH-medulloblastoma accelerates tumor formation by disrupting the BCOR-PRC1.1 complex and increasing Igf2 expression.
bioRxiv · Feb 6, 2020Cancer Biology