Author

B. Statz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 4 Approach:deep learning· 4 Organism:human· 4 Research Focus:clustering· 3 Research Focus:differential expression· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

A. Korshunov· 4 shared K. Okonechnikov· 4 shared S. M. Pfister· 4 shared A. Rademacher· 3 shared D. T. W. Jones· 3 shared J.-P. Mallm· 3 shared K. Rippe· 3 shared L. M. Kutscher· 3 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

A. Korshunov

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cell-state plasticity drives heterogeneity in Group 3/4 medulloblastoma

P. Joshi, P. B. G. da Silva, K. Okonechnikov, T. Stelzer, I. Sarropoulos, M. Sepp, J. Nolle, M. V. Pour-Jamnani, A. Rademacher, T. Yamada, C. Schneider, J. Schmidt, L. Bianchini, P. Schaefer, K. Leiss, , L. M. Kutscher

This study identifies cell-state plasticity as a driver of heterogeneity in Group 3/4 medulloblastomas, showing that transcription factor perturbation can redirect tumor cells along different differentiation trajectories.

bioRxiv · Feb 9, 2024 · PreprintCancer Biology

Medulloblastoma oncogene aberrations are not involved in tumor initiation, but essential for disease progression and therapy resistance

K. Okonechnikov, P. Joshi, V. Koerber, A. Rademacher, M. Bortolomeazzi, J.-P. Mallm, P. B. G. da Silva, B. Statz, M. Sepp, I. Sarropoulos, T. Yamada-Saito, J. Vaillant, A. Wittmann, K. Schramm, M. Blattner-Johnson, , S. M. Pfister

The paper uses single-cell technologies to show that large-scale chromosomal aberrations drive medulloblastoma initiation, while single-gene oncogenic events like MYC contribute to progression and therapy resistance.

bioRxiv · Feb 9, 2024Cancer Biology

Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage

D. R. Ghasemi, K. Okonechnikov, A. Rademacher, S. Tirier, K. K. Maass, H. Schumacher, J. Sundheimer, B. Statz, A. S. Rifaioglu, K. Bauer, S. Schumacher, M. Bortolomeazzi, F. Giangaspero, K. J. Ernst, J. Saez-Rodriguez, , K. W. Pajtler

The paper uses single-cell transcriptomics to show how two compartments in medulloblastoma are connected through a migrating precursor stage, revealing spatial and developmental links between proliferating and differentiated tumor cells.

Nature Communications · Jan 8, 2024Peer-reviewedCancer Biology

Functional loss of a non-canonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation

L. M. Kutscher, K. Okonechnikov, N. V. Batora, J. Clark, P. B. G. Silva, M. Vouri, S. van Rijn, L. Sieber, B. Statz, M. D. Gearhart, N. Mack, B. A. Orr, A. Korshunov, A. L. Mercier, O. Ayrault, , D. Kawauchi

This study shows that loss of BCOR in SHH-medulloblastoma accelerates tumor formation by disrupting the BCOR-PRC1.1 complex and increasing Igf2 expression.

bioRxiv · Feb 6, 2020Cancer Biology

Profiling immunoglobulin repertoires across multiple human tissues by RNA Sequencing

S. Mangul, I. Mandric, H. T. Yang, N. Strauli, D. Montoya, J. Rotman, W. V. Der Wey, J. R. Ronas, B. Statz, A. Zelikovsky, R. Spreafico, S. Shifman, N. Zaitlen, M. Rossetti, K. M. Ansel, E. Eskin

The paper develops ImReP, a computational method to profile TCR and BCR repertoires from RNA-seq data, creating a large atlas of immunological sequences across 53 tissues.

bioRxiv · Nov 6, 2018 · PreprintImmunology