Cancer BiologybioRxiv
Functional loss of a non-canonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation
L. M. Kutscher, K. Okonechnikov, N. V. Batora…·D. Kawauchi
This study shows that loss of BCOR in SHH-medulloblastoma accelerates tumor formation by disrupting the BCOR-PRC1.1 complex and increasing Igf2 expression.
DOI 10.1101/gad.337584.120