J. Clark

Dissecting human monoclonal antibody responses from mRNA- and protein-based XBB.1.5 COVID-19 monovalent vaccines

This study evaluates monoclonal antibody responses to XBB.1.5 vaccines by analyzing plasmablasts from vaccinated individuals and characterizing their binding and neutralization properties against SARS-CoV-2 variants.

Perfusion-Independent Tissue Hypoxia in Cardiac Hypertrophy in Mice Measured by 64Cu-CTS PET Imaging

This study shows that 64Cu-CTS PET detects hypoxia in hypertrophic mouse hearts independent of perfusion, linking it to structural changes and metabolic shifts.

TRIP12 governs DNA Polymerase β involvement in DNA damage response and repair

This study identifies TRIP12 as a regulator of DNA polymerase β involvement in DNA damage response and repair by controlling its trafficking and chromatin loading.

Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination

This study identifies non-neutralizing antibodies from vaccinated individuals that protect against SARS-CoV-2 in animal models, highlighting their role through Fc-mediated effector functions and conserved epitope binding.

Exploring the impact of microbial manipulation on the early development of kelp (Saccharina latissima) using an ecological core microbiome framework.

This study identifies core bacterial taxa associated with wild kelp and tests their impact on cultivated kelp growth, finding a positive correlation between bacterial frequency and developmental effect.

An evolutionary timescale for Bacteria calibrated using the Great Oxidation Event

This paper uses machine learning and phylogenetic reconciliation to estimate the evolutionary timeline of Bacteria, linking transitions to aerobic lifestyles to the Great Oxidation Event.

Functional Genomics of Gastrointestinal Escherichia coli Isolated from Patients with Cancer and Diarrhea

The paper investigates E. coli strains from cancer patients with diarrhea, finding novel adherence patterns and high antibiotic resistance gene carriage.

Contrasting the open access dissemination of COVID-19 and SDG research

The paper compares open access rates of COVID-19 and SDG research, finding lower open access for SDG topics despite publisher commitments.

Immunity to seasonal coronavirus spike proteins does not protect from SARS-CoV-2 challenge in a mouse model but has no detrimental effect on protection mediated by COVID-19 mRNA vaccination

This study investigates whether immunity to seasonal coronavirus spike proteins protects against SARS-CoV-2 in mice and affects mRNA vaccine efficacy, finding no increased protection but no detrimental effect on vaccination.

Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device

This paper introduces a method for real-time single-molecule protein sequencing using a semiconductor device, capable of detecting peptides and post-translational modifications with high sensitivity.

Comparative genomics of Acinetobacter baumannii and therapeutic bacteriophages from a patient undergoing phage therapy

This study reports the genomes of phages and A. baumannii isolates from a phage therapy case, showing rapid resistance development and identifying capsule locus mutations linked to phage insensitivity.

Salt-inducible kinase (SIK) inhibition is protective in a mouse model of asthma

This study shows that inhibiting SIKs reduces IL-13 secretion from ILC2s and alleviates allergic asthma symptoms in mice.

Temporal dynamics of base excision / single-strand break repair protein complex assembly and disassembly are modulated by the PARP1/NAD+/SIRT6 axis

The paper investigates the role of the PARP1/NAD+/SIRT6 axis in modulating the assembly and disassembly of DNA repair protein complexes during base excision repair.

Environmental effects on genetic variance are likely to constrain adaptation in novel environments

This study examines how genetic variance in leaf traits changes across elevations in two Sicilian daisy species and finds that environmental effects on genetic variance may limit adaptation in novel environments.

Increased adaptive potential in novel environments can be predicted from genetic variance in development time expressed in native environments

The paper shows that genetic variation in development time in native environments predicts survival in novel environments, with faster development linked to better survival.

Biodegradable and Biocompatible Graphene-based Scaffolds for Functional Neural Tissue Engineering: A Strategy Approach Using Dental Pulp Stem Cells and Biomaterials

This study evaluates the biological effects of 3D graphene oxide-based scaffolds on dental pulp stem cells, showing improved cell viability and reduced cytotoxicity.

Artificial light at night leads to circadian disruption in a songbird: integrated evidence from behavioural, genomic and metabolomic data

This study shows artificial light at night disrupts circadian rhythms in great tits, with shifts in gene expression and metabolomic profiles indicating circadian disruption across tissues.

Hidden genetic variation in plasticity increases the potential to adapt to novel environments

The paper shows that genetic variation in plasticity increases in novel environments and correlates with fitness, suggesting it aids adaptation despite being hidden in native environments.

Broiler Chickens and Early Life Programming: Microbiome transplant-induced cecal bacteriome dynamics and phenotypic effects

This study investigates how early-life microbiome exposure affects cecal microbiome dynamics and bird health by comparing transplanted cecal material to environmental inocula in broiler chickens.

Functional loss of a non-canonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation

This study shows that loss of BCOR in SHH-medulloblastoma accelerates tumor formation by disrupting the BCOR-PRC1.1 complex and increasing Igf2 expression.

Adaptive divergence generates distinct plastic responses in two closely related Senecio species

This study compares plastic responses of two closely related Senecio species to environmental variation, finding distinct adaptive divergence in their traits and gene expression across elevation gradients.

Sodium-powered stators of the bacterial flagellar motor can generate torque in the presence of phenamil with mutations near the peptidoglycan-binding region.

The paper identifies mutations in the sodium-powered bacterial flagellar motor stator PotB that confer resistance to phenamil, showing that mutations near the peptidoglycan-binding region enable motor function in the presence of the inhibitor.

PI3Kδ hyper-activation promotes the development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

This study identifies a PI3Kδ-driven B cell subset in the lungs that worsens Streptococcus pneumoniae infection independently of antibodies, and shows that inhibiting PI3Kδ improves survival.

C. elegans DBL-1/BMP Regulates Lipid Accumulation via Interaction with Insulin Signaling

This study shows DBL-1/BMP signaling in C. elegans regulates lipid accumulation through interaction with insulin signaling, affecting lipid droplet size and count.