Author

L. Simula

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Colamatteo· 1 shared A. Lupo-Mansuet· 1 shared C. Procaccini· 1 shared C. Tripodo· 1 shared D. An· 1 shared D. Damotte· 1 shared E. Donnadieu· 1 shared F. Pendino· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

A. Colamatteo

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Mitochondrial metabolism sustains CD8+ T cellmigration for an efficient infiltration into solid tumors

L. Simula, M. Fumagalli, L. Vimeux, I. Rajnpreht, P. Icard, D. An, F. Pendino, D. Damotte, A. Lupo-Mansuet, M. Alifano, M.-C. Alves-Guerra, E. Donnadieu

This study shows mitochondrial metabolism, not glycolysis, is essential for CD8+ T cell migration in 3D tumor environments, and enhancing mitochondrial activity improves CAR T cell infiltration and tumor control.

bioRxiv · Jan 12, 2024Immunology

PD-1-induced T cell exhaustion is controlled by a Drp1-dependent mechanism

L. Simula, V. Cancila, Y. Antonucci, A. Colamatteo, C. Procaccini, G. Matarese, C. Tripodo, S. Campello

This study shows PD-1 signalling reduces Drp1 activity in tumor-infiltrating T cells, leading to mitochondrial fusion and impaired T cell function.

bioRxiv · Jul 14, 2020Immunology