D. An

SLC13A2-transported citrate is a metabolic signal for PKM2 acetylation and degradation to suppress tumor growth

This paper identifies SLC13A2-transported citrate as a metabolic signal that promotes PKM2 acetylation and degradation, thereby suppressing tumor growth in hepatocellular carcinoma.

Mitochondrial metabolism sustains CD8+ T cellmigration for an efficient infiltration into solid tumors

This study shows mitochondrial metabolism, not glycolysis, is essential for CD8+ T cell migration in 3D tumor environments, and enhancing mitochondrial activity improves CAR T cell infiltration and tumor control.

Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production.

This study shows that bacterial sphingolipids worsen colitis by reducing IL-22 production from ILC3 cells in mice.

Efficacy of Parainfluenza Virus 5 (PIV5)-vectored Intranasal COVID-19 Vaccine as a Single Dose Vaccine and as a Booster against SARS-CoV-2 Variants

This paper evaluates the immunogenicity and efficacy of PIV5-vectored COVID-19 vaccines against SARS-CoV-2 variants in hamsters, showing they induce strong neutralizing antibodies and provide protection as single doses or boosters.

Microbial Nanocellulose Biotextiles for a Circular Materials Economy

This paper develops microbial nanocellulose biotextiles with enhanced mechanical and flame-retardant properties, demonstrating a sustainable alternative to conventional textiles with significantly reduced environmental impact.

Why are SNAREpins rod-shaped?

This study uses simulations to show rod-shaped SNAREpins are necessary for efficient membrane fusion via entropic forces.

A hemifused complex is the hub in a network of pathways to membrane fusion

The paper develops a mathematical model to explain how a dynamic hemifusion complex determines the outcome of cation-mediated membrane fusion.

Membrane pore energetics and the pathways to membrane rupture

This study uses simulations to show that membrane rupture occurs through different pathways depending on tension, without requiring long-lived metastable pore states.

Biocontrol of PGPR strain Bacillus amyloliquefaciens Ba168 against Phytophthora nicotianae on tobacco

This paper evaluates the biocontrol potential of PGPR strain Ba168 against tobacco black shank caused by Phytophthora nicotianae, showing it is effective but slightly less than a chemical mixture.

A global perspective on microbial diversity in the terrestrial deep subsurface

This study analyzes microbial diversity in the terrestrial deep subsurface using 16S rRNA gene data, finding that aquifer lithology controls bacterial community diversity and identifying a core microbial consortium across different rock types.

Gut-innervating nociceptor neurons protect against enteric infection by modulating the microbiota and Peyer’s patch microfold cells

This study shows gut-innervating nociceptors protect against Salmonella typhimurium infection by modulating microbiota and Peyer’s patch microfold cells.

HiAlc Klebsiella pneumonia, one of potential chief culprits of non-alcoholic fatty liver disease: through generation of endogenous ethanol

This study identifies HiAlc Klebsiella pneumoniae as a contributor to non-alcoholic fatty liver disease by inducing endogenous ethanol production in mice and humans.

Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence

This study shows that Pho84 in Candida albicans affects virulence by modulating oxidative stress through Sod3 and TORC1 pathways.