E. Donnadieu

Mitochondrial metabolism sustains CD8+ T cellmigration for an efficient infiltration into solid tumors

This study shows mitochondrial metabolism, not glycolysis, is essential for CD8+ T cell migration in 3D tumor environments, and enhancing mitochondrial activity improves CAR T cell infiltration and tumor control.

Tissue-resident FOLR2+ macrophages associate with tumor-infiltrating CD8+ T cells and with increased survival of breast cancer patients.

The paper identifies FOLR2+ macrophages in breast cancer that correlate with improved patient survival and co-localize with CD8+ T cells across multiple cancers.

CAR T cell entry into tumor islets is a two-step process dependent on IFNγ and ICAM-1

This study shows CAR T cell entry into tumor islets occurs in two steps, requiring IFNγ and ICAM-1 for effective infiltration.

Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

This study shows that inhibiting collagen crosslinking reduces tumor stiffness, enhances T cell migration, and improves anti-PD-1 treatment efficacy in mouse tumor models.

TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors

This study shows that TGFβ inhibits IFNα/β production and tumor rejection in spontaneous mammary tumors, and blocking TGFβ enhances DMXAA-induced tumor regression.

Blockade of β-adrenergic receptor signaling improves cancer vaccine efficacy through its effect on naive CD8+ T-cell priming

This study shows that blocking β-adrenergic receptor signaling enhances cancer vaccine efficacy by improving naive CD8+ T-cell priming, without affecting tumor-infiltrating CD8+ T-cell reactivity.