Cryo-EM Structure of the Pol Polyprotein Provides Insights into HIV Maturation
J. J. E. K. Harrison, D. O. Passos, J. F. Bruhn, J. D. Bauman, L. Tuberty, J. J. DeStefano, F. X. Ruiz, D. Lyumkis, E. Arnold
The paper determines the cryo-EM structure of the HIV-1 Pol polyprotein intermediate, revealing how RT dimerization activates proteolytic processing by bringing PR monomers together.
bioRxiv · Oct 3, 2021 · PreprintBiophysics