E. Arnold

Design of SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model

The paper designs SARS-CoV-2 PLpro inhibitors that show antiviral efficacy in a mouse model against SARS-CoV-2 and its variants.

Kinetic co-evolutionary models predict the temporal emergence of HIV resistance mutations under drug selection pressure

This paper uses kinetic co-evolutionary models to predict the temporal emergence of HIV resistance mutations under drug selection pressure, showing that epistasis determines DRM acquisition rates.

The Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening

The paper introduces the Halo Library, a set of halogenated fragments that improves the success rate of X-ray crystallographic fragment screening by identifying binding sites and hot spots on proteins.

Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro

The paper elucidates the structural basis and cleavage order of SARS-CoV-2 nsp7-11 polyprotein processing by Mpro, with implications for Mpro inhibition.

Cryo-EM structures of Doravirine and Rilpivirine with HIV-1 Reverse Transcriptase/DNA Aptamer: Nonnucleoside Inhibitor Resistance by E138K and M184I Mutations

The paper determines cryo-EM structures of HIV-1 reverse transcriptase with nonnucleoside inhibitors, revealing structural changes due to resistance mutations.

Transcriptional profiles of a foliar fungal endophyte (Pestalotiopsis, Ascomycota) and its endohyphal bacterium (Luteibacter, Gammaproteobacteria) in co-culture support sulfur exchange and growth regulation

This study uses dual RNA-seq to compare gene expression of a foliar fungal endophyte and its endohyphal bacterium in co-culture and axenic conditions, revealing sulfur exchange and potential role of type VI secretion system in symbiosis.

Cryo-EM Structure of the Pol Polyprotein Provides Insights into HIV Maturation

The paper determines the cryo-EM structure of the HIV-1 Pol polyprotein intermediate, revealing how RT dimerization activates proteolytic processing by bringing PR monomers together.

Resolving the Dynamic Motions of SARS-CoV-2 nsp7 and nsp8 Proteins Using Structural Proteomics

This study uses HDX-MS and XL-MS to analyze the structural dynamics of the full-length SARS-CoV-2 nsp7:nsp8 complex, revealing conformational flexibility and a different assembly model compared to SARS-CoV.

Crystal Structure of a Retroviral Polyprotein:Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT)

This paper reports the crystal structure of prototype foamy virus protease-reverse transcriptase (PR-RT), revealing its monomeric architecture and domain organization compared to HIV-1 enzymes.