Microbe-derived indole tunes organ-function and links microbe metabolites to biological ageing
P. Y. Xing, A. Jayaraman, G. W. Zhang, K. A. Martin, L. E. Faylon, S. Kjelleberg, S. A. Rice, Y. Wang, A. T. Bello, E. Holmes, J. Nicholson, L. Whiley, S. Pettersson
This study shows that indole, a gut microbe metabolite, is essential for maintaining organ function and metabolic homeostasis, and its deficiency leads to multiorgan decline and accelerated biological ageing.
bioRxiv · Jan 24, 2023 · PreprintMicrobiology