Exploring the Free Energy Landscape and Thermodynamics of Protein-Protein AssociationAssociation: HIV-1 Integrase Multimerization Induced by an Allosteric Inhibitor
N. Deng, C. Tse, L. Wickstrom, M. Kvaratskhelia, E. Gallicchio, R. Levy
This paper investigates the thermodynamics and free energy landscape of HIV-1 integrase multimerization induced by an allosteric inhibitor, revealing short-range interactions and enthalpy-driven binding.
bioRxiv · Jun 29, 2020Biophysics