R. Levy

Evolutionary sequence and structural basis for the distinct conformational landscapes of Tyr and Ser/Thr kinases

The paper investigates the structural basis for the distinct conformational landscapes of tyrosine and serine/threonine kinases using sequence and structure-based models.

A new archaeal virus that suppresses the transcription of host immunity genes

This paper discovers a new archaeal virus that suppresses host immunity gene transcription, leading to faster growth of its host when the virus is removed.

Temporal genomic analysis of melanoma rejection identifies regulators of tumor immune evasion

The paper identifies Mif as a regulator of tumor immune evasion in low intra-tumor heterogeneity melanoma by analyzing single-cell RNA sequencing data and validating in patient data.

Elucidating the molecular determinants for binding modes of a third-generation HIV-1 integrase strand transfer inhibitor: Importance of side chain and solvent reorganization

This study identifies molecular determinants of binding modes for a third-generation HIV-1 integrase inhibitor, showing that side chain and solvent reorganization, along with conformational entropy, influence ligand binding preferences in closely related viral intasomes.

Kinetic co-evolutionary models predict the temporal emergence of HIV resistance mutations under drug selection pressure

This paper uses kinetic co-evolutionary models to predict the temporal emergence of HIV resistance mutations under drug selection pressure, showing that epistasis determines DRM acquisition rates.

Comparison between optical tissue clearing methods for detecting administered mesenchymal stromal cells in mouse lungs

This study compares optical tissue clearing methods to detect mesenchymal stromal cells in mouse lungs, finding that CUBIC enables direct imaging of fluorescently labeled MSCs and their interaction with host cells.

Computed tomography lacks sensitivity to image gold labelled mesenchymal stromal cells in vivo as evidenced by multispectral optoacoustic tomography.

The paper compares imaging modalities for tracking gold-labelled mesenchymal stromal cells in vivo, finding that CT lacks sensitivity compared to BLI and MSOT.

Inhibition of advanced glycation end product formation and serum protein infiltration in bioprosthetic heart valve leaflets: Investigations of anti-glycation agents.

This study investigates anti-AGE agents' effects on AGE and serum protein infiltration in bioprosthetic heart valves using in vitro and in vivo models, finding that PYR significantly inhibits AGE and serum albumin accumulation.

Development of amyloid beta gold nanorod aggregates as optoacoustic probes

This study develops gold nanorod-based probes to track amyloid beta seeds in animal models, showing stability and safety in vitro.

The Shigella type III effector protein OspB is a cysteine protease

This paper identifies OspB as a cysteine protease in Shigella spp. and shows it interacts with the TORC1 pathway in yeast through proteolytic cleavage of Tco89p.

The role of epistasis in determining the fitness landscape of HIV proteins

This paper investigates epistasis in HIV proteins, showing strong evidence for long-range epistasis through sequence models but weak evidence from experimental fitness measures.

An mRNA SARS-CoV-2 vaccine employing Charge-Altering Releasable Transporters with a TLR-9 agonist induces neutralizing antibodies and T cell memory

This paper develops an mRNA SARS-CoV-2 vaccine using CARTs with a TLR-9 agonist, showing it induces neutralizing antibodies and T cell memory in mice.

In vitro evaluation of the activity of terpenes and cannabidiol against Human Coronavirus E229

The paper evaluates a terpene-based formulation, NT-VRL-1, and its combination with CBD against HCoV-229E in human lung fibroblasts, showing enhanced antiviral effects compared to controls.

Exploring the Free Energy Landscape and Thermodynamics of Protein-Protein AssociationAssociation: HIV-1 Integrase Multimerization Induced by an Allosteric Inhibitor

This paper investigates the thermodynamics and free energy landscape of HIV-1 integrase multimerization induced by an allosteric inhibitor, revealing short-range interactions and enthalpy-driven binding.

Charge-Altering Releasable Transporters enable specific phenotypic manipulation of resting primary natural killer cells

This study introduces CARTs, a non-viral transfection method for primary human NK cells, enabling efficient mRNA delivery without activation, preserving phenotype and function, and demonstrating therapeutic potential.

4D imaging and analysis of multicellular tumour spheroid cell migration and invasion

This study uses 4D imaging to analyze 3D cell migration and invasion in glioblastoma spheroids, evaluating chemotherapy efficacy on invasion.

Stem cell delivery to kidney via minimally invasive ultrasound-guided renal artery injection in mice

This study demonstrates that ultrasound-guided renal artery injection can effectively deliver and retain a large proportion of stem cells in the kidney of mice for 3 days.

In vivo fate of free and encapsulated iron oxide nanoparticles after injection of labelled stem cells

This study compares the in vivo fate of free and encapsulated iron oxide nanoparticles after labeling stem cells, finding both formulations accumulate in liver and spleen and are not fully cleared after two weeks.

Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration

The paper uses non-invasive imaging to study how cell type, administration route, and immune status affect the fate and safety of administered human and murine cells in mice.

Multimodal cell tracking from systemic administration to tumour growth by combining gold nanorods and reporter genes

This paper combines gold nanorods and reporter genes to track cells over time in mice, showing biodistribution and tumour growth.

Evaluation of quantum dot conjugated antibodies for immunofluorescent labelling of cellular targets

This study evaluates a commercially available quantum dot conjugated antibody for immunofluorescent labelling and finds it only binds to some cytosolic proteins and fails to reach the nucleus.

Experimental and Computational Investigation of the Structure of Peptide Monolayers on Gold Nanoparticles

The paper develops a computational model of peptide-capped gold nanoparticles, validated by experiments, revealing new structural features of monolayers.