Author

Lanijah Flagg

University of Chicago

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Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1

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Arvind MuruganiD· 1 shared David PincusiD· 1 shared Kabir B. HusainiD· 1 shared

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Arvind MuruganORCID

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Evolutionary BiologybioRxivPreprintOct 16, 2026

A DNA-barcoded Luria-Delbrück assay resolves mechanisms of adaptation

Kabir B. Husain, Lanijah Flagg, David Pincus, Arvind Murugan

This paper introduces HiDenSeq, a DNA-barcoded Luria-Delbrück assay that uses deep sequencing to analyze adaptation mechanisms by resolving the Luria-Delbrück distribution over four orders of magnitude.

DOI 10.64898/2026.08.03.742544

experimental assay

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