BiophysicsbioRxivPreprint
Mechanism of pharmacochaperoning in KATP channels revealed by cryo-EM
Gregory M. Martin, Min Woo Sung, Zhongying Yang…·Show-Ling Shyng
This study reveals how pharmacochaperones stabilize KATP channels by binding to SUR1 and supporting Kir6.2 N-terminus insertion, enabling mutant channel assembly.