Systems BiologybioRxivPreprint
A quantitative interactome map reveals affinity tailored hijacking of human cellular functions by resident and pathogenic bacteria
Jaime Fernandez-Macgregor, Laura Ilari, Fabien Durbesson…·Renaud Vincentelli
The paper reports a large-scale quantitative interactome of human PDZ domains and bacterial PDZ-binding motifs, showing bacteria tailor effector sequences to bind with similar or higher affinity than human PBMs to hijack host functions.
DOI 10.64898/2026.10.02.755967