BiophysicsbioRxiv
Oncogenic mutations of the EGF-Receptor ectodomain reveal an unexpected mechanism for ligand-independent activation
LAURA ORELLANA, ADAM HOSPITAL, MODESTO OROZCO
The paper identifies an unexpected intermediate conformation in EGFR ectodomain mutants that reveals a shared structural mechanism for ligand-independent activation and EGFRvIII deletion.
DOI 10.1073/pnas.1821442116