Cancer BiologybioRxivPreprint
FGFR1 inhibition prevents metabolic adaptation associated with therapy resistance in glioblastoma
Laura Zarzuela, Ignacio G. López-Cepero, Kevin M. Rattigan…·Raúl V. Durán
This study identifies FGFR1 as a key driver of TMZ resistance in GBM through metabolic rewiring and cell cycle regulation, showing that FGFR1 inhibition restores TMZ sensitivity in preclinical models.
DOI 10.1101/2025.01.11.632515