Leah C. Fuller

This study shows that phosphorylation of a shared C-terminal motif in γ-Protocadherin negatively regulates dendrite arborization in cortical neurons, with a C-terminal deletion causing the strongest phenotype.

This study shows that γ-protocadherin isoforms are critical for synapse formation and peripheral branching in touch sensory neurons, and their loss disrupts corticospinal synapses.

The paper uses CRISPR/Cas9 to disrupt isoforms of the Pcdhg gene cluster in mice, finding that Pcdhgc4 is the only critical isoform for neuronal function.