Targeting and anchoring the mechanosensitive ion channel Piezo to facilitate its inhibition of axon regeneration
Qin Wang, Leanne Miles, Shuo Wang, Lilly M. Ryll, Harun Najib Noristani, Ethan Schauer, Ernest John Monahan Vargas, Jackson Ross Powell, Sean J O'Rourke-Ibach, Naiara Akizu, Jill Wildonger, Shuxin Li, Yuanquan Song
This study identifies a pathway involving Rtca, Rab10, and Itgb1 that regulates Piezo localization and function, promoting axon regeneration inhibition in Drosophila and mice.
PLoS Genetics · Dec 1, 2025Peer-reviewedNeuroscience