Author

Leighton J Core

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Adam SiepeliD· 1 shared Andre L Martins· 1 shared Charles G Danko· 1 shared Colin T Waters· 1 shared Dig B Mahat· 1 shared Fabiana M Duarte· 1 shared Hyung Won Lee· 1 shared John T Lis· 1 shared

Activity by Year

2014-2016 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenomics

Adam SiepelORCID

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2 papers

Recent·Most cited

Transcription factors GAF and HSF act at distinct regulatory steps to modulate stress-induced gene activation

Fabiana M Duarte, Nicholas J Fuda, Dig B Mahat, Leighton J Core, Michael Guertin, John T Lis

This study investigates the distinct roles of transcription factors GAF and HSF in the heat shock response in Drosophila using PRO-seq, revealing their separate functions in Pol II pausing and release during gene activation.

bioRxiv · May 27, 2016Genomics

Accurate Identification of Active Transcriptional Regulatory Elements from Global Run-On and Sequencing Data

Charles G Danko, Stephanie L Hyland, Leighton J Core, Andre L Martins, Colin T Waters, Hyung Won Lee, Vivian G Cheung, W. Lee Kraus, John T. Lis, Adam Siepel

The paper introduces dREG, a machine-learning method to identify active transcriptional regulatory elements from GRO-seq data, showing strong enrichment for functional marks.

bioRxiv · Nov 12, 2014Genomics