Cell BiologybioRxivPreprint
Inflammatory proteostasis reprogramming creates a lysosomal bottleneck for microglial aggregate clearance
Frederik Eikens, Lena Wischhof, Anna Henrich…·Hannah Scheiblich
This study shows that inflammatory activation impairs microglial degradation of protein aggregates by creating a lysosomal bottleneck, without affecting their uptake.
DOI 10.64898/2026.11.02.763615