Leonid A Mirny

This paper proposes that loop extrusion by cohesins and boundary proteins like CTCF forms Topologically Associating Domains (TADs) through dynamic loop creation and stabilization.

This study shows that increasing passenger DNA alterations in cancer cells reduces their fitness, slows tumor growth, and may serve as a biomarker for tumor aggressiveness and therapy response.

The paper develops a stochastic model of mutation dynamics in cancer, showing how driver and passenger mutations interact to influence tumor progression and treatment outcomes.