Bo Zhu

The paper develops a genetically encoded green fluorescent IP3 biosensor for detecting IP3 signals across concentrations and visualizing its signaling network with cAMP and Ca2+.

The paper introduces SMART, a single-molecule display platform for enzyme engineering, and demonstrates its application in evolving D-amino acid oxidase with improved substrate specificity.

This study presents a method to comprehensively profile protease cleavage specificity using in vitro selection, high-throughput sequencing, and mass spectrometry, revealing extended spectrum preferences for broad specificity proteases.

This study shows that targeting endothelial FOXO1 reduces IGF2 levels, improves β-cell function, and enhances wound healing in diabetes.

This paper introduces a method to increase gene expression from linear DNA templates in cell-free systems by using DNA-binding proteins, achieving significant yield improvements in both E. coli and Vibrio natriegens.