Cancer BiologyCell Reports MedicinePeer-reviewed
CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality
Jean Ching-Yi Tien, Jie Luo, Yu Chang…·Arul M. Chinnaiyan
This study shows CDK12 loss drives prostate cancer development and identifies CDK13 as a therapeutic target through paralog-based synthetic lethality in CDK12-mutant tumors.
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