NeurosciencebioRxivPreprint
Diverging Parkinson's Disease Pathology between GBAN370S ,LRRK2G2019S and engineered SNCAA53T iPSC-derived Dopaminergic Neurons
Ali Fathi, Kiranmayee Bakshy, Lida Zieghami…·Jing Liu
This study compares dopamine neuron phenotypes from PD patients with mutations in GBAN370S and LRRK2G2019S to engineered SNCAA53T iPSC-derived neurons, revealing divergent pathogenic mechanisms and potential therapeutic targets.