Lili Donner

Elevated IL-1 beta plasma levels, altered platelet activation and cardiac remodeling lead to moderately decreased LV function in Alzheimer transgenic mice after myocardial ischemia and reperfusion

This study shows that Alzheimer's transgenic mice experience reduced left ventricular function after myocardial ischemia and reperfusion, linked to elevated IL-1 beta, altered platelet activation, and cardiac remodeling.

Platelets from early-stage Alzheimer patients show enhanced amyloid binding, an elevated open canalicular system and sex-specific differences in their activation profile

The paper shows that platelets from early-stage Alzheimer's patients bind more amyloid-beta, have altered morphology, and show sex-specific activation differences, suggesting potential as biomarkers for AD.

Long-term antiplatelet therapy protects against cerebral but not parenchymal amyloid plaque formation and neurodegeneration in transgenic mice of Alzheimers disease

This study shows that long-term antiplatelet therapy with clopidogrel reduces cerebral amyloid angiopathy and soluble Aβ42 levels but not parenchymal amyloid plaques or neurodegeneration in APP23 mice.

Cryo-EM Structures of Amyloid-β Fibrils from Alzheimer's Disease Mouse Models

The paper presents cryo-EM structures of Aβ fibrils from Alzheimer's disease mouse models and compares them to human fibrils.