Margitta Elvers

This study identifies dysregulated GPIb alpha-VWF signalling in AAA, showing increased platelet GPIb alpha expression and VWF activity in patients and mice.

This study shows that Alzheimer's transgenic mice experience reduced left ventricular function after myocardial ischemia and reperfusion, linked to elevated IL-1 beta, altered platelet activation, and cardiac remodeling.

This study identifies a novel CD36-TSP-1 signaling pathway that modulates platelet-RBC interaction, promoting thrombus formation and contributing to abdominal aortic aneurysm pathology.

The paper shows that platelets from early-stage Alzheimer's patients bind more amyloid-beta, have altered morphology, and show sex-specific activation differences, suggesting potential as biomarkers for AD.

This study shows that long-term antiplatelet therapy with clopidogrel reduces cerebral amyloid angiopathy and soluble Aβ42 levels but not parenchymal amyloid plaques or neurodegeneration in APP23 mice.

This study shows that GPVI-mediated platelet activation worsens AAA by promoting inflammation and aortic wall remodeling, suggesting GPVI as a therapeutic target.

This study shows that platelets induce cardiac cell apoptosis via FasL after acute myocardial infarction, contributing to cardiac damage and dysfunction.

This study shows platelets worsen AAA by promoting inflammation, ECM degradation, and osteopontin release, with platelet depletion reducing aneurysm growth.

The paper presents cryo-EM structures of Aβ fibrils from Alzheimer's disease mouse models and compares them to human fibrils.