Assessment of single cell RNA-seq normalization methods
This study evaluates seven single cell RNA-seq normalization methods using diluted RNA data, finding that methods incorporating spike-in ERCC RNA outperform those without.
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This study evaluates seven single cell RNA-seq normalization methods using diluted RNA data, finding that methods incorporating spike-in ERCC RNA outperform those without.
Hannah R. Dueck, Rizi Ai, Adrian Camarena…·Junhyoung Kim
This study evaluates the performance of three scRNA-seq methods through controlled experiments, finding they reliably detect genes above 5-10 molecules with linear measurement transfer functions.
Bo Ding, Lina Zheng, David Medovoy, Wei Wang
The paper identifies cancer-specific genotype variations that target 3D chromosomal hubs, altering local interactions and revealing principles of genome organization.