Childhood brain tumours instruct cranial haematopoiesis and immunotolerance
Elizabeth Alexandra Cooper, David A Posner, Colin Y.C. Lee…·Richard J. Gilbertson
This study identifies a mechanism by which skull bone marrow-derived HSPCs and CD4+ T cells promote immunotolerance in childhood brain tumours, showing that antibody therapy targeting CSF cytokines can disrupt this process and induce tumour regression.