Cancer BiologybioRxivPreprint
A screen for combination therapies in BRAF/NRAS wild type melanoma identifies nilotinib plus MEK inhibitor as a synergistic combination
Marco Ranzani, Kristel Kemper, Magali Michaut…·David J. Adams
DOI 10.1101/195354
Author
Lodewyk Wessels
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2016-2017 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 36 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship4 papers
Recent·Most cited
- BioinformaticsScientific ReportsPeer-reviewed
Logic models to predict continuous outputs based on binary inputs with an application to personalized cancer therapy
Theo Knijnenburg, Gunnar Klau, Francesco Iorio…·Lodewyk Wessels
The paper introduces LOBICO, a logic modeling approach for binary inputs predicting continuous outputs, showing it outperforms single-gene predictors in cancer drug response.
DOI 10.1038/srep36812 - BioinformaticsbioRxiv
A novel independence test for somatic alterations in cancer shows that biology drives mutual exclusivity but chance explains co-occurrence
Sander Canisius, John Martens, Lodewyk Wessels
This paper introduces DISCOVER, a new statistical test for analyzing somatic alterations in cancer, showing it outperforms existing methods and reveals more mutual exclusivity than co-occurrence.
DOI 10.1186/s13059-016-1114-x - BioinformaticsbioRxiv
OncoScape: Exploring the cancer aberration landscape by genomic data fusion
Andreas Schlicker, Magali Michaut, Rubayte Rahman, Lodewyk Wessels
OncoScape integrates five genomic data types across 11 cancer types to identify new candidate cancer genes and reveals discrepancies between cell line and tumor aberrations.
DOI 10.1038/srep28103