Cancer BiologyGenePeer-reviewed
Repair of leukemia-associated single nucleotide variants via interallelic gene conversion
Alexander James Silver, Donovan J. Brown, Sarah D. Olmstead…·Michael Robert Savona
This study demonstrates that CRISPR-mediated interallelic gene conversion can revert heterozygous SNVs in leukemia cells without exogenous templates, improving survival in xenograft models.
4 citations