Author

Longhua Gu

Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Likun GongiD· 2 shared Yiru LongiD· 2 shared Fanglin LiiD· 1 shared Fanglin LiiD· 1 shared Jiang-ling Lu· 1 shared Jianhua SuniD· 1 shared Jianhua Sun· 1 shared Jing CheniD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

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10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

Likun GongORCID

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2 papers

Recent·Most cited

ImmunologyActa Pharmacologica SinicaPeer-reviewedSep 2, 2024

INHBA/Activin A promotes tumor growth and induces resistance to anti-PD-L1 therapy by suppressing IFN-γ signaling

Fanglin Li, Longhua Gu, Yong-liang Tong…·Likun Gong

This study shows that INHBA/activin A suppresses IFN-γ signaling, leading to resistance to anti-PD-L1 therapy and promoting tumor growth.

27 citationstop 4%

humanbulk RNA-seq

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ImmunologybioRxivPreprintMar 5, 2024

CMTM6 maintains B cell intrinsic CD40 expression to regulate anti-tumor immunity

Yiru Long, Runqiu Chen, Wenlong Chang…·Likun Gong

This study shows that CMTM6 in B cells maintains CD40 membrane levels by inhibiting its degradation, which is essential for B cell activation, anti-tumor immunity, and the effectiveness of CD40 agonists and ICB therapy.

DOI 10.1101/2024.03.05.583639

mouseexperimental assay

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