Author

Longzhi Cao

National Institute of Biological Sciences, Beijing

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1

Frequent Co-Authors

Panrui Lu· 2 shared Ting HaniD· 2 shared Yalong ChengiD· 2 shared Chao LiiD· 1 shared Chenglong CheniD· 1 shared Dengfeng DouiD· 1 shared Jiaojiao LiiD· 1 shared Jinguo LiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

Panrui Lu

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2 papers

Recent·Most cited

BiochemistryACS Chemical BiologyPeer-reviewedApr 9, 2025

TRIM21-NUP98 interface accommodates structurally diverse molecular glue degraders

Yalong Cheng, Longzhi Cao, Panrui Lu…·Ting Han

The paper identifies multiple molecular glue degraders that target the TRIM21-NUP98 interface, showing its ability to accommodate structurally diverse compounds.

15 citationstop 4%

experimental assaydrug response / drug discovery

𝕏 PostBluesky

Pharmacology & ToxicologyCellPeer-reviewedNov 1, 2024

Selective degradation of multimeric proteins via chemically induced proximity to TRIM21

Panrui Lu, Yalong Cheng, Lei Xue…·Ting Han

This study identifies acepromazine as a compound that selectively degrades multimeric proteins via TRIM21 activation, offering a new strategy for targeting disease-related protein assemblies.

119 citationstop 1%

humanexperimental assay

𝕏 PostBluesky