Author

Lucas Brusselle

Inserm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Research Focus:cell type annotation· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Jérémie PoschmanniD· 3 shared Cynthia FourgeuxiD· 2 shared Jean‐François MosnieriD· 2 shared Martin BraudiD· 2 shared Adrien Lannes· 1 shared Amédée RenandiD· 1 shared Anaïs CardoniD· 1 shared Andreas SchlitzeriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

Jérémie PoschmannORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cross-species chromatin accessibility pinpoints HIVEP3 as a driver of thymic epithelial maturation and self-antigen expression, preventing chronic inflammation

Sümeyye Yayilkan, Marie Massoda, Séverine Ménoret, Axel You, Lucas Brusselle, Claire Usal, Laurent Tesson, Mathieu Rouel, Flore Couzy, Francine Padonou, Cloé Zamit, Jérémy C. Santamaria, Pierre Maminirina, Olivier Baron, Jérôme Jullien, , Matthieu Giraud

This study identifies HIVEP3 as a critical regulator of thymic epithelial maturation and self-antigen expression, with its deficiency causing chronic inflammation.

bioRxiv · Jun 19, 2026 · PreprintImmunology

A JAK-STAT-activated myeloid hub at ulceration sites underlies resistance to anti-TNF therapy in Crohn's disease

Thomas Laurent, Monika Mykhaylyshyn, Jake Thomas, Gaëlle Bériou, Lucas Otero-Laudouar, Lucas Brusselle, Aurélie Joussaume, Cécile Braudeau, Justine Chevreuil, Cynthia Fourgeux, Laurence Bouchet‐Delbos, Martin Braud, Nicolas Chapelle, Mathieu Uzzan, Pablo Canales-Herrerías, , J. P. D. Martin

The paper identifies a JAK-STAT-activated myeloid subset, IFIM, associated with anti-TNF resistance in Crohn's disease and proposes JAK inhibition as a therapeutic strategy.

bioRxiv · Feb 13, 2026 · PreprintImmunology

The immune profile of circulating autoreactive CD4 T cells is imprinted through tissue activation during autoimmune liver diseases

Anaïs Cardon, Thomas Guinebretière, Chuang Dong, Laurine Gil, Sakina Ado, Pierre-Jean Gavlovsky, Martin Braud, Richard Danger, Christoph Schultheiß, Aurélie Doméné, Perrine Paul‐Gilloteaux, Caroline Chevalier, Laura Bernier, Jean‐Paul Judor, Cynthia Fourgeux, , Amédée Renand

This study identifies the transcriptional profile of circulating autoreactive CD4 T cells in autoimmune liver diseases and shows their functional relationship to liver-specific pathogenic clones.

Nature Communications · Jan 29, 2025Peer-reviewedImmunology