Cynthia Fourgeux

This study shows that the PGC-1α Gly482Ser SNP reprograms oxidative metabolism to favor energy storage, especially in females, through reduced respiratory capacity and altered metabolic responses.

The paper identifies a JAK-STAT-activated myeloid subset, IFIM, associated with anti-TNF resistance in Crohn's disease and proposes JAK inhibition as a therapeutic strategy.

The paper investigates TDG's role in cell differentiation by showing its involvement in ATF4-dependent gene transcription during retinoic acid-induced neural fate commitment.

This study generates functional thymic epithelial cells from iPSCs that support T cell development and dendritic cell differentiation in vitro.

The paper identifies a dynamic gene regulatory network in Duchenne muscular dystrophy that controls cell fate decisions and shows how disease mutations disrupt this network.

The paper shows that sperm-derived H2AK119ub1 is essential for embryonic development in Xenopus laevis by guiding epigenetic remodelling of paternal chromatin.

This study identifies the transcriptional profile of circulating autoreactive CD4 T cells in autoimmune liver diseases and shows their functional relationship to liver-specific pathogenic clones.

SCellBOW identifies and risk-stratifies tumor cell subpopulations using scRNA-seq data by simulating their impact on disease prognosis.