BiochemistrybioRxivPreprint
Taccalonolide AJ uncouples tubulin GTP hydrolysis from microtubule depolymerization
Ezekiel C. Thomas, Nicholas E. Vangos, Lauren A McCormick…·Michael A. Cianfrocco
This study shows that taccalonolide AJ stabilizes microtubules through a mechanism distinct from paclitaxel, promoting a compacted, post-GTP hydrolysis state that resists depolymerization.
DOI 10.64898/2026.09.30.755716