Kristen J. Verhey

The paper demonstrates that motors can shepherd diffusive proteins on microtubules through biased diffusion, revealing a mechanism for spatial patterning without direct binding.

This study shows that taccalonolide AJ stabilizes microtubules through a mechanism distinct from paclitaxel, promoting a compacted, post-GTP hydrolysis state that resists depolymerization.

This study identifies KIFBP-regulated kinesins during neuronal development using proteomic and imaging approaches, revealing KIF5A and KIF18B as novel targets.

This study identifies CLASP2 as a factor that facilitates microtubule repair in response to damage caused by kinesin-1 motor proteins.

This study identifies structural switches in tubulin that Taxol exploits to stabilize microtubules by reverting them to a pre-hydrolysis state.

This study investigates how MATCAP1 binds to expanded microtubule conformations to generate detyrosinated and ΔC2 α-tubulin modifications.

The paper investigates the accessibility of the α-tubulin C-terminal tail (Y-CTT) and finds it is regulated by microtubule lattice conformation through nucleotide state and MAP interactions.

This study uses live-cell imaging to show that KIF1A remains attached to cargo during axonal transport and is degraded afterward, supporting the Diligent Worker model.

The paper investigates how multi-kinesin clusters induce mechanical stress leading to microtubule breakage, estimating a lower rupture force than previous in vitro studies.

This study shows KIF1C's C-terminal IDR drives LLPS, enabling RNA transport and revealing a new mode of motor-cargo interaction.

This study identifies KIF17 as a dual regulator of Hedgehog signaling in cerebellar development, with opposing roles in Purkinje cells and granule neuron progenitors.

The paper investigates the role of Kif6 in ependymal cilia motility and polarity, finding that its loss causes decreased cilia movement and hydrocephalus in mice.

The paper identifies VAB-8/KIF26 as a key molecule mediating synaptic cargo delivery at microtubule minus-ends, linking Neurexin and Frizzled signaling to synapse formation in C. elegans.

This study identifies a new regulatory mechanism of KIF1A motility through K-loop interactions with polyglutamylated microtubule C-terminal tails, revealing how pausing behavior contributes to superprocessive transport.