Alveolar Epithelial Cell Loss of the Mitochondrial Regulator TFAM Drives Progressive Lung Fibrosis
Qianjiang Hu, Ugochi Onwuka, Nayra Cárdenes, M Packwood, E L Huang, Jian Shi, M. Camila Melo-Narváez, Puja Dutta, Zihe Zhou, Delphine Beaulieu, Byron W. Chuan, Pavan Suresh, Kevin Redding, Laura-Marie Twardowski, Scarlett Varley, , Mélanie Königshoff
This study shows that loss of TFAM in alveolar type 2 cells leads to mitochondrial dysfunction and fibrosis by promoting senescence and a profibrotic secretory program.
bioRxiv · Jul 18, 2026 · PreprintPathology