John Sembrat

This study analyzes an H5N5 influenza virus isolate that caused a human fatality, finding it lacks key traits associated with human pandemic potential.

This study shows that loss of TFAM in alveolar type 2 cells leads to mitochondrial dysfunction and fibrosis by promoting senescence and a profibrotic secretory program.

This study identifies Gcn5l1 as a heart-specific factor that modulates cholesterol metabolism and heart-to-liver crosstalk in cardiometabolic heart failure, revealing the heart's role in systemic metabolic dysfunction.

The paper develops SenSet, a gene signature for human lung senescence, validated in 3D culture models and identifies cell-type specific senescence mechanisms in aging and disease.

This study shows IFI16, regulated by m6A modification, drives inflammatory endothelial changes in pulmonary arterial hypertension.

The paper identifies transcription factor networks driving fibrotic lung disease using multiomic single-cell data from SSc-ILD and control lungs.

This study shows GCN5L1 prevents Rictor degradation in cardiac cells under hypoxia by acetylating Rictor, thereby maintaining Akt/mTORC2 signaling and protecting against ischemic injury.

The paper identifies TWIST1 as a critical regulator of myofibroblast activity in IPF using single-nucleus ATAC-seq and scRNA-seq integration.