Mélanie Königshoff

This study shows that loss of TFAM in alveolar type 2 cells leads to mitochondrial dysfunction and fibrosis by promoting senescence and a profibrotic secretory program.

This study analyzes lung epithelial cells across the lifespan in mice, identifying age-related declines in regeneration linked to inflammation and epigenetic changes.

This study shows that Siglec-F protects against elastase-induced lung inflammation and emphysema by regulating airspace macrophages in mice.

The paper uses single-cell RNA-seq to analyze aging effects on lung regeneration, identifying immune cell states linked to impaired progenitor function in aged mice.

This paper introduces DeepSAS, a deep graph framework to identify senescent cells and their associated genes, revealing cell-type-specific senescence features in aging and disease.

Single-nucleus multiomic and ex vivo lung slice profiling of human idiopathic pulmonary fibrosis identifies Alveolar Intermediate cells bridging alveolar and Aberrant Basaloid states and reveals AP-1 chromatin injury memory.

The paper develops SenSet, a gene signature for human lung senescence, validated in 3D culture models and identifies cell-type specific senescence mechanisms in aging and disease.

The paper develops scDOT, a method combining spatial transcriptomics and single-cell RNA-seq with optimal transport to improve spatial mapping of senescent cells and identify novel genes involved in cell-cell interactions.

This study shows that primary human lung fibroblasts from different disease origins exhibit similar susceptibility to senescence induction but distinct senescent programs, which impair alveolar epithelial progenitor function.

The paper uses single-cell RNA-seq to identify Krt8+ progenitor cells involved in lung regeneration and shows their role in epithelial differentiation and disease.