Author

M. A. Giardini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:non-human primate· 1 Approach:statistical model· 1

Frequent Co-Authors

D. Skinner· 2 shared J. H. McKerrow· 2 shared J. L. Siqueira-Neto· 2 shared P. Fajtova· 2 shared A. Drelich· 1 shared A. E. Clark· 1 shared A. F. Carlin· 1 shared A. J. O'Donoghue· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

D. Skinner

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2 papers

Recent·Most cited

BiochemistrybioRxivJan 5, 2022

Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2

L. H. Santos, T. Kronenberger, R. G. Almeida…·R. Ferreira

This study identifies naphthoquinone derivatives as inhibitors of SARS-CoV-2 proteases Mpro and PLpro through virtual screening and biochemical assays.

DOI 10.1021/acs.jcim.2c00693

virusproteomics

𝕏 PostBluesky

BiochemistrybioRxivPreprintOct 23, 2020

A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells

D. Mellott, C.-T. Tseng, A. Drelich…·J. H. McKerrow

This paper shows that K777, a cysteine protease inhibitor, blocks SARS-CoV-2 infection by inhibiting host cathepsin L, which is required for spike protein processing, with nanomolar efficacy in several cell lines.

DOI 10.1101/2020.10.23.347534

humannon-human primate

𝕏 PostBluesky