D. Skinner

A revision of the Neotropical Costaceae: results from sixty years of taxonomic struggle

This paper revises the Neotropical Costaceae family, describing 90 species across four genera and providing taxonomic updates, distribution maps, and identification tools.

Development of subunit selective proteasome substrates for Schistosoma species

The paper develops subunit-specific proteasome substrates for Schistosoma species, showing improved performance and cross-species applicability.

Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2

This study identifies naphthoquinone derivatives as inhibitors of SARS-CoV-2 proteases Mpro and PLpro through virtual screening and biochemical assays.

Discovery of Potent Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L

This paper identifies potent triple inhibitors targeting SARS-CoV-2 proteases and human cathepsin L, showing improved potency and antiviral effects compared to disulfiram.

Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L

A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells

This paper shows that K777, a cysteine protease inhibitor, blocks SARS-CoV-2 infection by inhibiting host cathepsin L, which is required for spike protein processing, with nanomolar efficacy in several cell lines.

Quantifying the mechanics of locomotion of the schistosome pathogen with respect to changes in its physical environment

This study quantifies the biomechanics of schistosome locomotion in different physical environments and identifies key motility parameters that could inform drug development.