BiophysicsbioRxiv
Resolving conformational changes that mediate a two-step catalytic mechanism in a model enzyme
J. B. Greisman, K. M. Dalton, D. E. Brookner…·D. R. Hekstra
This study identifies conformational changes in DHFR that mediate its two-step catalytic mechanism through experimental perturbations and X-ray diffraction.
DOI 10.1073/pnas.2313192121