Author

I.-S. Kim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Batyuk· 1 shared A. Bhowmick· 1 shared A. Butryn· 1 shared A. Goldstein· 1 shared A. M. Orville· 1 shared A. Muscallera· 1 shared A. S. Brewster· 1 shared C. J. Sheehan· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperBiochemistry

A. Batyuk

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dual-mode action of scalable, high-quality engineered stem cell-derived SIRPα-extracellular vesicles for treating acute liver failure

S. Kim, Y. K. Kim, S. Kim, Y.-S. Choi, I. Lee, H. Joo, J. Kim, M. Kwon, S. Park, M. K. Jo, Y. Choi, T. D'Souza, J. W. Jung, E. Zakhem, S. Lenzini, , I.-S. Kim

This paper develops SIRPα-expressing extracellular vesicles from engineered stem cells to treat acute liver failure by resolving necroptosis and promoting liver regeneration, showing reduced liver damage and improved survival in models.

bioRxiv · May 24, 2024Bioengineering

Resolving conformational changes that mediate a two-step catalytic mechanism in a model enzyme

J. B. Greisman, K. M. Dalton, D. E. Brookner, M. A. Klureza, C. J. Sheehan, I.-S. Kim, R. W. Henning, S. Russi, D. R. Hekstra

This study identifies conformational changes in DHFR that mediate its two-step catalytic mechanism through experimental perturbations and X-ray diffraction.

bioRxiv · Jun 2, 2023Biophysics

Redox-controlled structural reorganization and flavin strain within the ribonucleotide reductase R2b-NrdI complex monitored by serial femtosecond crystallography

J. John, O. Aurelius, V. Srinivas, I.-S. Kim, A. Bhowmick, P. S. Simon, M. Dasgupta, C. Pham, S. Gul, K. D. Sutherlin, P. Aller, A. Butryn, A. M. Orville, M. H. Cheah, S. Owada, , M. Hogbom

The paper uses serial femtosecond crystallography to study redox-induced structural changes in the R2b-NrdI complex, revealing flavin strain and its role in superoxide generation.

bioRxiv · Apr 14, 2022Biochemistry

Phenotypic plasticity of ER+ breast cancer in the bone microenvironment

I. L. Bado, H. Wang, P. Sarkar, J. Liu, W. Wu, W. Zhang, H.-C. Lo, A. Muscallera, M. Janghorban, I.-S. Kim, S. Singh, A. Goldstein, P. Singh, H. Shixia, G. M. Waleed, , X. H. F. Zhang

The paper shows that the bone microenvironment induces endocrine resistance in ER+ breast cancer metastases through epigenomic reprogramming mediated by EZH2.

bioRxiv · Nov 14, 2020 · PreprintCancer Biology